Crystallography Open Database

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1566281 CIFC43 H62 F6 N4 O5.5 PP -113.1015; 13.9905; 14.3129
103.697; 99.4485; 117.548
2142.83Guillou, Amaury; Nisli, Eda; Klingler, Simon; Linden, Anthony; Holland, Jason P.
Photoactivatable Fluorescent Tags for Dual-Modality Positron Emission Tomography Optical Imaging.
Journal of medicinal chemistry, 2022, 65, 811-823
1564798 CIFC23 H31 Cl O4P 1 21 16.7959; 36.5395; 8.7513
90; 98.87; 90
2147.12Luo, Xiaowei; Cai, Guodi; Guo, Yinfeng; Gao, Chenghai; Huang, Weifeng; Zhang, Zhenhua; Lu, Humu; Liu, Kai; Chen, Jianghe; Xiong, Xiaofeng; Lei, Jinping; Zhou, Xuefeng; Wang, Junjian; Liu, Yonghong
Exploring Marine-Derived Ascochlorins as Novel Human Dihydroorotate Dehydrogenase Inhibitors for Treatment of Triple-Negative Breast Cancer.
Journal of medicinal chemistry, 2021, 64, 13918-13932
1501660 CIFC26 H26 N2 O2P 21 21 2111.2339; 11.6808; 16.4783
90; 90; 90
2162.3Trapella, Claudio; Pela, Michela; Del Zoppo, Luisa; Calo, Girolamo; Camarda, Valeria; Ruzza, Chiara; Cavazzini, Alberto; Costa, Valentina; Bertolasi, Valerio; Reinscheid, Rainer K.; Salvadori, Severo; Guerrini, Remo
Synthesis and separation of the enantiomers of the neuropeptide S receptor antagonist (9R/S)-3-oxo-1,1-diphenyl-tetrahydro-oxazolo[3,4-a]pyrazine-7-carboxylic acid 4-fluoro-benzylamide (SHA 68).
Journal of medicinal chemistry, 2011, 54, 2738-2744
1504341 CIFC21 H34 N2 O3C 1 2 119.155; 5.871; 19.432
90; 96.031; 90
2173.2Gomtsyan, Arthur; Bayburt, Erol K.; Schmidt, Robert G.; Surowy, Carol S.; Honore, Prisca; Marsh, Kennan C.; Hannick, Steven M.; McDonald, Heath A.; Wetter, Jill M.; Sullivan, James P.; Jarvis, Michael F.; Faltynek, Connie R.; Lee, Chih-Hung
Identification of (R)-1-(5-tert-butyl-2,3-dihydro-1H-inden-1-yl)-3-(1H-indazol-4-yl)urea (ABT-102) as a potent TRPV1 antagonist for pain management.
Journal of medicinal chemistry, 2008, 51, 392-395
1502666 CIFC19 H28 B10 OC 1 2 124.701; 6.5249; 18.081
90; 131.621; 90
2178.5Beer, Michael L.; Lemon, Jennifer; Valliant, John F.
Preparation and evaluation of carborane analogues of tamoxifen.
Journal of medicinal chemistry, 2010, 53, 8012-8020
1517245 CIFC16 H28 N4 O10 PtP 21 21 218.9059; 11.2218; 22.076
90; 90; 90
2206.3Varbanov, Hristo P.; Göschl, Simone; Heffeter, Petra; Theiner, Sarah; Roller, Alexander; Jensen, Frank; Jakupec, Michael A.; Berger, Walter; Galanski, Markus; Keppler, Bernhard K.
A Novel Class of Bis- and Tris-Chelate Diam(m)inebis(dicarboxylato)platinum(IV) Complexes as Potential Anticancer Prodrugs.
Journal of medicinal chemistry, 2014, 57, 6751-6764
1517246 CIFC16 H31 N3 O11 PtP 1 21/n 113.8623; 8.618; 18.7397
90; 97.841; 90
2217.81Varbanov, Hristo P.; Göschl, Simone; Heffeter, Petra; Theiner, Sarah; Roller, Alexander; Jensen, Frank; Jakupec, Michael A.; Berger, Walter; Galanski, Markus; Keppler, Bernhard K.
A Novel Class of Bis- and Tris-Chelate Diam(m)inebis(dicarboxylato)platinum(IV) Complexes as Potential Anticancer Prodrugs.
Journal of medicinal chemistry, 2014, 57, 6751-6764
1553261 CIFC27 H32 N2 O4P 1 21/c 19.41991; 10.1144; 23.7285
90; 91.6653; 90
2259.82Zhang, Xiao-Ru; Wang, Hao-Wen; Tang, Wen-Lin; Zhang, Yu; Yang, Hui; Hu, De-Xuan; Ravji, Azhar; Marchand, Christophe; Kiselev, Evgeny; Ofori-Atta, Kwabena; Agama, Keli; Pommier, Yves; An, Lin-Kun
Discovery, Synthesis, and Evaluation of Oxynitidine Derivatives as Dual Inhibitors of DNA Topoisomerase IB (TOP1) and Tyrosyl-DNA Phosphodiesterase 1 (TDP1), and Potential Antitumor Agents.
Journal of medicinal chemistry, 2018, 61, 9908-9930
1505685 CIFC18 H24 B2 F8 N6 RuP 1 21/c 18.4268; 13.5307; 19.9593
90; 91.305; 90
2275.2Vock, Carsten A.; Scolaro, Claudine; Phillips, Andrew D.; Scopelliti, Rosario; Sava, Gianni; Dyson, Paul J.
Synthesis, characterization, and in vitro evaluation of novel ruthenium(II) eta6-arene imidazole complexes.
Journal of medicinal chemistry, 2006, 49, 5552-5561
1506349 CIFC14 H16 Cu Fe N10 O5 SP 1 21/n 113.157; 13.641; 14.205
90; 115.98; 90
2291.8Belicchi-Ferrari, Marisa; Bisceglie, Franco; Casoli, Claudio; Durot, Stéphanie; Morgenstern-Badarau, Irène; Pelosi, Giorgio; Pilotti, Elisabetta; Pinelli, Silvana; Tarasconi, Pieralberto
Copper(II) and cobalt(III) pyridoxal thiosemicarbazone complexes with nitroprusside as counterion: syntheses, electronic properties, and antileukemic activity.
Journal of medicinal chemistry, 2005, 48, 1671-1675
1566549 CIFC26 H23 Br N6 OP -112.22; 12.7328; 16.424
76.485; 82.598; 67.698
2296.6Wittmann, Christopher; Bacher, Felix; Enyedy, Eva A.; Dömötör, Orsolya; Spengler, Gabriella; Madejski, Christian; Reynisson, Jóhannes; Arion, Vladimir B.
Highly Antiproliferative Latonduine and Indolo[2,3-<i>c</i>]quinoline Derivatives: Complex Formation with Copper(II) Markedly Changes the Kinase Inhibitory Profile.
Journal of medicinal chemistry, 2022, 65, 2238-2261
1557183 CIFC26 H28 N4 O5P 4111.7728; 11.7728; 17.1159
90; 90; 90
2372.2Yang, Yaxi; Zhang, Rukang; Li, Zhaojun; Mei, Lianghe; Wan, Shili; Ding, Hong; Chen, Zhifeng; Xing, Jing; Feng, Huijin; Han, Jie; Jiang, Hualiang; Zheng, Mingyue; Luo, Cheng; Zhou, Bing
Discovery of Highly Potent, Selective, and Orally Efficacious p300/CBP Histone Acetyltransferases Inhibitors.
Journal of medicinal chemistry, 2020
1502668 CIFC16 H10 N3P 1 21/c 115.046; 9.845; 16.267
90; 98.773; 90
2381.4Tan, Caiping; Lai, Sensen; Wu, Shouhai; Hu, Sheng; Zhou, Lingjun; Chen, Yu; Wang, Minxu; Zhu, Yiping; Lian, Wu; Peng, Wenlie; Ji, Liangnian; Xu, Anlong
Nuclear permeable ruthenium(II) β-carboline complexes induce autophagy to antagonize mitochondrial-mediated apoptosis.
Journal of medicinal chemistry, 2010, 53, 7613-7624
1505025 CIFC27 H26 Cl2 N2 RuP 1 21/c 114.34; 12.4234; 15.156
90; 117.502; 90
2394.9Vock, Carsten A.; Ang, Wee Han; Scolaro, Claudine; Phillips, Andrew D.; Lagopoulos, Lucienne; Juillerat-Jeanneret, Lucienne; Sava, Gianni; Scopelliti, Rosario; Dyson, Paul J.
Development of ruthenium antitumor drugs that overcome multidrug resistance mechanisms.
Journal of medicinal chemistry, 2007, 50, 2166-2175
1557185 CIFC25 H23 F4 N5 O5P 110.1492; 10.1392; 25.2626
96.515; 96.515; 107.35
2435.42Yang, Yaxi; Zhang, Rukang; Li, Zhaojun; Mei, Lianghe; Wan, Shili; Ding, Hong; Chen, Zhifeng; Xing, Jing; Feng, Huijin; Han, Jie; Jiang, Hualiang; Zheng, Mingyue; Luo, Cheng; Zhou, Bing
Discovery of Highly Potent, Selective, and Orally Efficacious p300/CBP Histone Acetyltransferases Inhibitors.
Journal of medicinal chemistry, 2020
1557720 CIFC26 H26 F6 Ir N2 PP 1 21/c 115.2558; 10.7013; 15.9682
90; 110.221; 90
2446.2Carrasco, Ana C.; Rodríguez-Fanjul, Vanessa; Habtemariam, Abraha; Pizarro, Ana M.
Structurally Strained Half-Sandwich Iridium(III) Complexes As Highly Potent Anticancer Agents.
Journal of medicinal chemistry, 2020
1566736 CIFC15 H14 O3P 21 21 215.5437; 8.4551; 52.42
90; 90; 90
2457.06Müller, Christoph; Gleixner, Jakob; Tahk, Maris-Johanna; Kopanchuk, Sergei; Laasfeld, Tõnis; Weinhart, Michael; Schollmeyer, Dieter; Betschart, Martin U.; Lüdeke, Steffen; Koch, Pierre; Rinken, Ago; Keller, Max
Structure-Based Design of High-Affinity Fluorescent Probes for the Neuropeptide Y Y<sub>1</sub> Receptor.
Journal of medicinal chemistry, 2022, 65, 4832-4853
1559410 CIFC28 H27 N3 O7P 21 21 217.22366; 16.5577; 20.6478
90; 90; 90
2469.63Wang, Jinhui; Jin, Weiyang; Zhou, Xiaoxin; Li, Jiaqi; Xu, Chengdong; Ma, Zhongjun; Wang, Jianan; Qin, Lele; Zhou, Biao; Ding, Wanjing; Gao, Tingting; Yao, Hangping; Chen, Zhe
Identification, Structure‒Activity Relationships of Marine-Derived Indolocarbazoles, and a Dual PKCθ/δ Inhibitor with Potent Antipancreatic Cancer Efficacy
Journal of Medicinal Chemistry, 2020
1517164 CIFC23 H25 Cl F6 N3 O P RuP 1 21/n 19.887; 18.473; 14.002
90; 104.589; 90
2474.9Chow, Mun Juinn; Licona, Cynthia; Yuan Qiang Wong, Daniel; Pastorin, Giorgia; Gaiddon, Christian; Ang, Wee Han
Discovery and Investigation of Anticancer Ruthenium-Arene Schiff-Base Complexes via Water-Promoted Combinatorial Three-Component Assembly.
Journal of medicinal chemistry, 2014, 57, 6043-6059
1502661 CIFC48 H50 N16 Ni O11P -113.8735; 14.2569; 15.0005
106.463; 99.654; 113.031
2484.7Maldonado, Carmen R.; Marín, Clotilde; Olmo, Francisco; Huertas, Oscar; Quirós, Miguel; Sánchez-Moreno, Manuel; Rosales, María J; Salas, Juan M.
In vitro and in vivo trypanocidal evaluation of nickel complexes with an azapurine derivative against Trypanosoma cruzi.
Journal of medicinal chemistry, 2010, 53, 6964-6972
1502658 CIFC27 H23 Cl3 N4 O2P 21 21 2111.1695; 11.2252; 20.0044
90; 90; 90
2508.1Yan, Lin; Huo, Pei; Debenham, John S.; Madsen-Duggan, Christina B; Lao, Julie; Chen, Richard Z.; Xiao, Jing Chen; Shen, Chun-Pyn; Stribling, D. Sloan; Shearman, Lauren P.; Strack, Alison M.; Tsou, Nancy; Ball, Richard G.; Wang, Junying; Tong, Xinchun; Bateman, Thomas J.; Reddy, Vijay B. G.; Fong, Tung M.; Hale, Jeffrey J.
Discovery of N-[(4R)-6-(4-chlorophenyl)-7-(2,4-dichlorophenyl)-2,2-dimethyl-3,4-dihydro-2H-pyrano[2,3-b]pyridin-4-yl]-5-methyl-1H-pyrazole-3-carboxamide (MK-5596) as a novel cannabinoid-1 receptor (CB1R) inverse agonist for the treatment of obesity.
Journal of medicinal chemistry, 2010, 53, 4028-4037
1502670 CIFC26.5 H33 N O6.5P 1 21 15.1805; 17.2642; 28.104
90; 92.234; 90
2511.63Auzzas, Luciana; Larsson, Andreas; Matera, Riccardo; Baraldi, Annamaria; Deschênes-Simard, Benoît; Giannini, Giuseppe; Cabri, Walter; Battistuzzi, Gianfranco; Gallo, Grazia; Ciacci, Andrea; Vesci, Loredana; Pisano, Claudio; Hanessian, Stephen
Non-natural macrocyclic inhibitors of histone deacetylases: design, synthesis, and activity.
Journal of medicinal chemistry, 2010, 53, 8387-8399
1559413 CIFC29 H28 N4 O6P 1 21 115.4258; 8.2007; 20.1539
90; 98.481; 90
2521.64Wang, Jinhui; Jin, Weiyang; Zhou, Xiaoxin; Li, Jiaqi; Xu, Chengdong; Ma, Zhongjun; Wang, Jianan; Qin, Lele; Zhou, Biao; Ding, Wanjing; Gao, Tingting; Yao, Hangping; Chen, Zhe
Identification, Structure‒Activity Relationships of Marine-Derived Indolocarbazoles, and a Dual PKCθ/δ Inhibitor with Potent Antipancreatic Cancer Efficacy
Journal of Medicinal Chemistry, 2020
1557718 CIFC28 H26 F6 Ir N2 PP 1 21/c 115.8944; 10.8142; 15.7843
90; 111.606; 90
2522.46Carrasco, Ana C.; Rodríguez-Fanjul, Vanessa; Habtemariam, Abraha; Pizarro, Ana M.
Structurally Strained Half-Sandwich Iridium(III) Complexes As Highly Potent Anticancer Agents.
Journal of medicinal chemistry, 2020
1547327 CIFC31 H29 Fe N O4P 1 21/n 111.7418; 16.8025; 13.8536
90; 112.354; 90
2527.8Pigeon, Pascal; Wang, Yong; Top, Siden; Najlaoui, Feten; Garcia Alvarez, Maria Concepcion; Bignon, Jérôme; McGlinchey, Michael J.; Jaouen, Gérard
A New Series of Succinimido-ferrociphenols and Related Heterocyclic Species Induce Strong Antiproliferative Effects, Especially against Ovarian Cancer Cells Resistant to Cisplatin.
Journal of medicinal chemistry, 2017, 60, 8358-8368
1507655 CIFC13 H15 Fe N O SeC 1 2/c 117.983; 7.4102; 19.235
90; 93.649; 90
2558Gutiérrez-Hernández, Alejandro I; López-Cortés, José G; Ortega-Alfaro, M Carmen; Ramírez-Apan, M Teresa; Cázares-Marinero, José de Jesús; Toscano, Rubén A
Ferrocenylselenoamides: synthesis, characterization and cytotoxic properties.
Journal of medicinal chemistry, 2012, 55, 4652-4663
1553254 CIFC27 H28 Br N5 O3P 1 21 113.774; 18.775; 10.658
90; 110.084; 90
2588.6Xue, Yu; Song, Peiran; Song, Zilan; Wang, Aoli; Tong, Linjiang; Geng, Meiyu; Ding, Jian; Liu, Qingsong; Sun, Liping; Xie, Hua; Zhang, Ao
Discovery of 4,7-Diamino-5-(4-phenoxyphenyl)-6-methylene-pyrimido[5,4- b]pyrrolizines as Novel Bruton's Tyrosine Kinase Inhibitors.
Journal of medicinal chemistry, 2018, 61, 4608-4627
1506355 CIFC22 H32 Cl2 N2 O6 PtP 1 21/c 17.7485; 18.294; 18.356
90; 92.129; 90
2600.2Ang, Wee Han; Pilet, Sébastien; Scopelliti, Rosario; Bussy, François; Juillerat-Jeanneret, Lucienne; Dyson, Paul J.
Synthesis and characterization of platinum(IV) anticancer drugs with functionalized aromatic carboxylate ligands: influence of the ligands on drug efficacies and uptake.
Journal of medicinal chemistry, 2005, 48, 8060-8069
1512249 CIFC24 H27 Cl Cu N6 O PP 1 21/n 18.343; 15.605; 20.06
90; 95.36; 90
2600.2Gandin, Valentina; Porchia, Marina; Tisato, Francesco; Zanella, Alessandro; Severin, Emilia; Dolmella, Alessandro; Marzano, Cristina
Novel mixed-ligand copper(i) complexes: role of diimine ligands on cytotoxicity and genotoxicity.
Journal of medicinal chemistry, 2013, 56, 7416-7430
1516882 CIFC14 H13 I O2P b c a7.8201; 15.7081; 21.1791
90; 90; 90
2601.6Yang, Yanping; Cui, Mengchao; Zhang, Xiaoyang; Dai, Jiapei; Zhang, Zhiyong; Lin, Chunping; Guo, Yuzhi; Liu, Boli
Radioiodinated Benzyloxybenzene Derivatives: A Class of Flexible Ligands Target to β-Amyloid Plaques in Alzheimer's Brains.
Journal of medicinal chemistry, 2014, 57, 6030-6042
1560800 CIFC23 H28.5 Cl1.5 N8 O0.25 S2 ZnC 1 2/c 114.257; 11.4474; 17.156
90; 108.496; 90
2655.3Gilleran, John A.; Yu, Xin; Blayney, Alan J.; Bencivenga, Anthony F.; Na, Bing; Augeri, David J.; Blanden, Adam R.; Kimball, S. David; Loh, Stewart N.; Roberge, Jacques Y.; Carpizo, Darren R.
Benzothiazolyl and Benzoxazolyl Hydrazones Function as Zinc Metallochaperones to Reactivate Mutant p53.
Journal of medicinal chemistry, 2021, 64, 2024-2045
1512128 CIFC25 H22 Cl5 N2 P PdP 1 21/n 113.102; 14.328; 15.347
90; 111.72; 90
2676.5Lease, Nicholas; Vasilevski, Vadim; Carreira, Monica; de Almeida, Andreia; Sanaú, Mercedes; Hirva, Pipsa; Casini, Angela; Contel, María
Potential Anticancer Heterometallic Fe‒Au and Fe‒Pd Agents: Initial Mechanistic Insights
Journal of Medicinal Chemistry, 2013, 56, 5806
1559109 CIFC30 H38 O9P 21 21 217.402; 13.4298; 26.9766
90; 90; 90
2681.67Wang, Cheng; Li, Shang; Zhao, Jinhua; Yang, Huali; Yin, Fucheng; Ding, Ming; Luo, Jianguang; Wang, Xiao-Bing; Kong, Ling-Yi
Design and SAR of withangulatin A analogs that act as covalent TrxR inhibitors through Michael addition reaction showing potential in cancer treatment.
Journal of medicinal chemistry, 2020
1566544 CIFC28 H28 Br Cl Cu N6 O2P 1 21/c 116.1127; 8.9758; 19.2463
90; 103.825; 90
2702.85Wittmann, Christopher; Bacher, Felix; Enyedy, Eva A.; Dömötör, Orsolya; Spengler, Gabriella; Madejski, Christian; Reynisson, Jóhannes; Arion, Vladimir B.
Highly Antiproliferative Latonduine and Indolo[2,3-<i>c</i>]quinoline Derivatives: Complex Formation with Copper(II) Markedly Changes the Kinase Inhibitory Profile.
Journal of medicinal chemistry, 2022, 65, 2238-2261
1505033 CIFC28 H35 N O6P 21 21 218.6763; 14.897; 20.9747
90; 90; 90
2711Vyavahare, Vinod P.; Chakraborty, Chaitali; Maity, Biswanath; Chattopadhyay, Subrata; Puranik, Vedavati G.; Dhavale, Dilip D.
Synthesis of 1-deoxy-1-hydroxymethyl- and 1-deoxy-1-epi-hydroxymethyl castanospermine as new potential immunomodulating agents.
Journal of medicinal chemistry, 2007, 50, 5519-5523
1553262 CIFC29.2 H31.8 Cl Ir N5 O0.2P -19.804; 15.8991; 18.4457
82.7271; 86.7456; 72.239
2715.65Chen, Feng; Moat, John; McFeely, Daniel; Clarkson, Guy; Hands-Portman, Ian J; Furner-Pardoe, Jessica P; Harrison, Freya; Dowson, Christopher G.; Sadler, Peter J.
Biguanide Iridium(III) Complexes with Potent Antimicrobial Activity.
Journal of medicinal chemistry, 2018, 61, 7330-7344
1557314 CIFC33 H40 O4P 21 21 219.4737; 15.6173; 18.4421
90; 90; 90
2728.58Ye, Yan-Song; Li, Wen-Yan; Du, Shu-Zong; Yang, Jian; Nian, Yin; Xu, Gang
Congenetic hybrids derived from dearomatized isoprenylated acylphloroglucinol with opposite effects on Ca<sub>v</sub>3.1 low voltage-gated Ca<sup>2+</sup> channel.
Journal of medicinal chemistry, 2020
1553250 CIFC23 H31 F N3 O10 PC 1 2 130.024; 7.0591; 13.29
90; 101.32; 90
2761.9Peng, Youmei; Yu, Wenquan; Li, Ertong; Kang, Jinfeng; Wang, Yafeng; Yang, Qinghua; Liu, Bingjie; Zhang, Jingmin; Li, Longyu; Wu, Jie; Jiang, Jinhua; Wang, Qingduan; Chang, Junbiao
Discovery of an Orally Active and Liver-Targeted Prodrug of 5-Fluoro-2'-Deoxyuridine for the Treatment of Hepatocellular Carcinoma.
Journal of medicinal chemistry, 2016, 59, 3661-3670
1503675 CIFC52 H65 N4 O26.5 S4P -113.699; 13.796; 15.189
88.402; 77.838; 81.671
2776.6Wang, Kui; Guo, Dong-Sheng; Zhang, Hong-Qing; Li, Dong; Zheng, Xi-Long; Liu, Yu
Highly effective binding of viologens by p-sulfonatocalixarenes for the treatment of viologen poisoning.
Journal of medicinal chemistry, 2009, 52, 6402-6412
1503662 CIFC14 H13 N O3 S2P c a 2113.516; 9.108; 22.558
90; 90; 90
2777Agrawal, Arpita; de Oliveira, César Augusto F; Cheng, Yuhui; Jacobsen, Jennifer A.; McCammon, J. Andrew; Cohen, Seth M.
Thioamide hydroxypyrothiones supersede amide hydroxypyrothiones in potency against anthrax lethal factor.
Journal of medicinal chemistry, 2009, 52, 1063-1074
1557186 CIFC15 H14 N4 O2P 21 21 215.8178; 16.9835; 28.2863
90; 90; 90
2794.9Yang, Yaxi; Zhang, Rukang; Li, Zhaojun; Mei, Lianghe; Wan, Shili; Ding, Hong; Chen, Zhifeng; Xing, Jing; Feng, Huijin; Han, Jie; Jiang, Hualiang; Zheng, Mingyue; Luo, Cheng; Zhou, Bing
Discovery of Highly Potent, Selective, and Orally Efficacious p300/CBP Histone Acetyltransferases Inhibitors.
Journal of medicinal chemistry, 2020
1507499 CIFC12 H13 Br Cl N3 SP 1 21/c 121.335; 9.315; 14.491
90; 102.995; 90
2806.12Schröder, Jörg; Henke, Andreas; Wenzel, Herbert; Brandstetter, Hans; Stammler, Hans G.; Stammler, Anja; Pfeiffer, Wolf D.; Tschesche, Harald
Structure-Based Design and Synthesis of Potent Matrix Metalloproteinase Inhibitors Derived from a 6H-1,3,4-Thiadiazine Scaffold
Journal of Medicinal Chemistry, 2001, 44, 3231
1546508 CIFC31 H32 N6 Ni O3P 1 21 110.0992; 20.5006; 13.57
90; 90.2639; 90
2809.5McKinnie, Shaun M. K.; Wang, Wang; Fischer, Conrad; McDonald, Tyler; Kalin, Kevin R.; Iturrioz, Xavier; Llorens-Cortes, Catherine; Oudit, Gavin Y.; Vederas, John C.
Synthetic Modification within the "RPRL" Region of Apelin Peptides: Impact on Cardiovascular Activity and Stability to Neprilysin and Plasma Degradation.
Journal of medicinal chemistry, 2017, 60, 6408-6427
1546982 CIFC32 H35 N3 Ni O3P 1 21 111.1064; 21.5351; 12.1674
90; 105.031; 90
2810.6McKinnie, Shaun M. K.; Wang, Wang; Fischer, Conrad; McDonald, Tyler; Kalin, Kevin R.; Iturrioz, Xavier; Llorens-Cortes, Catherine; Oudit, Gavin Y.; Vederas, John C.
Synthetic Modification within the "RPRL" Region of Apelin Peptides: Impact on Cardiovascular Activity and Stability to Neprilysin and Plasma Degradation.
Journal of medicinal chemistry, 2017, 60, 6408-6427
1533374 CIFC30 H33 Cl F3 Ir N2 O2P 1 21/n 111.3662; 17.1523; 15.528
90; 111.111; 90
2824.1Yellol, Jyoti; Pérez, Sergio A; Buceta, Alicia; Yellol, Gorakh; Donaire, Antonio; Szumlas, Piotr; Bednarski, Patrick J.; Makhloufi, Gamall; Janiak, Christoph; Espinosa, Arturo; Ruiz, José
Novel C,N-Cyclometalated Benzimidazole Ruthenium(II) and Iridium(III) Complexes as Antitumor and Antiangiogenic Agents: A Structure-Activity Relationship Study.
Journal of medicinal chemistry, 2015, 58, 7310-7327
1533375 CIFC30 H32 Cl F3 N2 O2 RuP 1 21/c 112.5656; 17.1429; 13.9971
90; 108.785; 90
2854.5Yellol, Jyoti; Pérez, Sergio A; Buceta, Alicia; Yellol, Gorakh; Donaire, Antonio; Szumlas, Piotr; Bednarski, Patrick J.; Makhloufi, Gamall; Janiak, Christoph; Espinosa, Arturo; Ruiz, José
Novel C,N-Cyclometalated Benzimidazole Ruthenium(II) and Iridium(III) Complexes as Antitumor and Antiangiogenic Agents: A Structure-Activity Relationship Study.
Journal of medicinal chemistry, 2015, 58, 7310-7327
1559414 CIFC37 H29 N5 O5P 21 21 219.05425; 14.2458; 22.2227
90; 90; 90
2866.4Wang, Jinhui; Jin, Weiyang; Zhou, Xiaoxin; Li, Jiaqi; Xu, Chengdong; Ma, Zhongjun; Wang, Jianan; Qin, Lele; Zhou, Biao; Ding, Wanjing; Gao, Tingting; Yao, Hangping; Chen, Zhe
Identification, Structure‒Activity Relationships of Marine-Derived Indolocarbazoles, and a Dual PKCθ/δ Inhibitor with Potent Antipancreatic Cancer Efficacy
Journal of Medicinal Chemistry, 2020
1553257 CIFC H OP 21 21 216.9288; 7.9172; 52.844
90; 90; 90
2898.8Das, Pronay; Babbar, Palak; Malhotra, Nipun; Sharma, Manmohan; Jachak, Goraknath R.; Gonnade, Rajesh G.; Shanmugam, Dhanasekaran; Harlos, Karl; Yogavel, Manickam; Sharma, Amit; Reddy, D. Srinivasa
Specific Stereoisomeric Conformations Determine the Drug Potency of Cladosporin Scaffold against Malarial Parasite.
Journal of medicinal chemistry, 2018, 61, 5664-5678
1566547 CIFC60 H63 Br2 Cl N14 Ni O4P -19.7632; 15.6735; 19.622
87.172; 75.925; 85.319
2901.4Wittmann, Christopher; Bacher, Felix; Enyedy, Eva A.; Dömötör, Orsolya; Spengler, Gabriella; Madejski, Christian; Reynisson, Jóhannes; Arion, Vladimir B.
Highly Antiproliferative Latonduine and Indolo[2,3-<i>c</i>]quinoline Derivatives: Complex Formation with Copper(II) Markedly Changes the Kinase Inhibitory Profile.
Journal of medicinal chemistry, 2022, 65, 2238-2261
1502672 CIFC33 H52 O3P 21 21 217.2672; 11.8653; 33.6544
90; 90; 90
2901.94Genet, Cédric; Strehle, Axelle; Schmidt, Céline; Boudjelal, Geoffrey; Lobstein, Annelise; Schoonjans, Kristina; Souchet, Michel; Auwerx, Johan; Saladin, Régis; Wagner, Alain
Structure-activity relationship study of betulinic acid, a novel and selective TGR5 agonist, and its synthetic derivatives: potential impact in diabetes.
Journal of medicinal chemistry, 2010, 53, 178-190

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