Crystallography Open Database

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1553257 CIFC H OP 21 21 216.9288; 7.9172; 52.844
90; 90; 90
2898.8Das, Pronay; Babbar, Palak; Malhotra, Nipun; Sharma, Manmohan; Jachak, Goraknath R.; Gonnade, Rajesh G.; Shanmugam, Dhanasekaran; Harlos, Karl; Yogavel, Manickam; Sharma, Amit; Reddy, D. Srinivasa
Specific Stereoisomeric Conformations Determine the Drug Potency of Cladosporin Scaffold against Malarial Parasite.
Journal of medicinal chemistry, 2018, 61, 5664-5678
1552562 CIFC10 H12 F2 N2 O5P 21 21 215.8735; 13.5166; 14.1374
90; 90; 90
1122.36Yoon, Ji-Seong; Kim, Gyudong; Jarhad, Dnyandev B.; Kim, Hong-Rae; Shin, Young-Sup; Qu, Shuhao; Sahu, Pramod K.; Kim, Hea Ok; Lee, Hyuk Woo; Wang, Su Bin; Kong, Yun Jeong; Chang, Tong-Shin; Ogando, Natacha S.; Kovacikova, Kristina; Snijder, Eric J.; Posthuma, Clara C.; van Hemert, Martijn J.; Jeong, Lak Shin
Design, Synthesis, and Anti-RNA Virus Activity of 6'-Fluorinated-Aristeromycin Analogues.
Journal of medicinal chemistry, 2019, 62, 6346-6362
1507789 CIFC10 H12 F3 N3 O5 PtP 1 21/c 118.336; 7.1871; 10.8106
90; 100.556; 90
1400.5Wilson, Justin J.; Lippard, Stephen J.
In Vitro Anticancer Activity of cis-Diammineplatinum(II) Complexes with β-Diketonate Leaving Group Ligands.
Journal of medicinal chemistry, 2012, 55, 5326-5336
1552560 CIFC10 H13 F N2 O5P 32 2 16.6465; 6.6465; 43.3632
90; 90; 120
1658.97Yoon, Ji-Seong; Kim, Gyudong; Jarhad, Dnyandev B.; Kim, Hong-Rae; Shin, Young-Sup; Qu, Shuhao; Sahu, Pramod K.; Kim, Hea Ok; Lee, Hyuk Woo; Wang, Su Bin; Kong, Yun Jeong; Chang, Tong-Shin; Ogando, Natacha S.; Kovacikova, Kristina; Snijder, Eric J.; Posthuma, Clara C.; van Hemert, Martijn J.; Jeong, Lak Shin
Design, Synthesis, and Anti-RNA Virus Activity of 6'-Fluorinated-Aristeromycin Analogues.
Journal of medicinal chemistry, 2019, 62, 6346-6362
5000285 CIFC10 H15 Br2 Cl3P 21 21 216.115; 12.456; 19.188
90; 90; 90
1461.52Fuller, Richard W.; Cardellina, John H.; Kato, Yoko; Brinen, Linda S.; Clardy, Jon; Snader, Kenneth M.; Boyd, Michael R.
A pentahalogenated monoterpene from the red alga Portieria hornemannii produces a novel cytotoxicity profile against a diverse panel of human tumor cell lines
Journal of Medicinal Chemistry, 1992, 35, 3007-3011
1507788 CIFC10 H15 N3 O5 PtP c a 219.4898; 15.218; 8.9436
90; 90; 90
1291.6Wilson, Justin J.; Lippard, Stephen J.
In Vitro Anticancer Activity of cis-Diammineplatinum(II) Complexes with β-Diketonate Leaving Group Ligands.
Journal of medicinal chemistry, 2012, 55, 5326-5336
1516003 CIFC10 H17 N5 O6P 21 21 217.1785; 10.0813; 17.096
90; 90; 90
1237.2Clinch, Keith; Watt, Derek K.; Dixon, Rachel A.; Baars, Sylvia M.; Gainsford, Graeme J.; Tiwari, Ashish; Schwarz, Günter; Saotome, Yas; Storek, Michael; Belaidi, Abdel A.; Santamaria-Araujo, Jose A
Synthesis of cyclic pyranopterin monophosphate, a biosynthetic intermediate in the molybdenum cofactor pathway.
Journal of medicinal chemistry, 2013, 56, 1730-1738
1505035 CIFC10 H4 O2 S2P 1 21/c 18.96; 14.8156; 6.7569
90; 102.962; 90
874.11Hyatt, Janice L.; Wadkins, Randy M.; Tsurkan, Lyudmila; Hicks, Latorya D.; Hatfield, M. Jason; Edwards, Carol C.; Ross, 2nd, Charles R; Cantalupo, Stephanie A.; Crundwell, Guy; Danks, Mary K.; Guy, R. Kip; Potter, Philip M.
Planarity and constraint of the carbonyl groups in 1,2-diones are determinants for selective inhibition of human carboxylesterase 1.
Journal of medicinal chemistry, 2007, 50, 5727-5734
1508515 CIFC10.5 H17 Cl2 N2 O4.5 PtP 1 21/c 113.66; 9.867; 23.937
90; 98.52; 90
3190.7Chin, Chee Fei; Tian, Quan; Setyawati, Magdiel Inggrid; Fang, Wanru; Tan, Emelyn Sue Qing; Leong, David Tai; Ang, Wee Han
Tuning the activity of platinum(IV) anticancer complexes through asymmetric acylation.
Journal of medicinal chemistry, 2012, 55, 7571-7582
1552561 CIFC11 H16 F2 N5 O4.5P 1 21 110.20373; 6.97368; 18.69692
90; 96.8278; 90
1320.99Yoon, Ji-Seong; Kim, Gyudong; Jarhad, Dnyandev B.; Kim, Hong-Rae; Shin, Young-Sup; Qu, Shuhao; Sahu, Pramod K.; Kim, Hea Ok; Lee, Hyuk Woo; Wang, Su Bin; Kong, Yun Jeong; Chang, Tong-Shin; Ogando, Natacha S.; Kovacikova, Kristina; Snijder, Eric J.; Posthuma, Clara C.; van Hemert, Martijn J.; Jeong, Lak Shin
Design, Synthesis, and Anti-RNA Virus Activity of 6'-Fluorinated-Aristeromycin Analogues.
Journal of medicinal chemistry, 2019, 62, 6346-6362
1518628 CIFC11 H17 Cl F N O Pt SP 1 21/c 15.9315; 12.1005; 19.7
90; 103.067; 90
1377.34Zamora, Ana; Pérez, Sergio A; Rodríguez, Venancio; Janiak, Christoph; Yellol, Gorakh S.; Ruiz, José
Dual Antitumor and Antiangiogenic Activity of Organoplatinum(II) Complexes.
Journal of medicinal chemistry, 2015, 58, 1320-1336
1503666 CIFC11 H20 N2 O2P 1 21 111.4279; 9.9784; 16.245
90; 93.967; 90
1848.01Fox, David J.; Reckless, Jill; Lingard, Hannah; Warren, Stuart; Grainger, David J.
Highly potent, orally available anti-inflammatory broad-spectrum chemokine inhibitors.
Journal of medicinal chemistry, 2009, 52, 3591-3595
1553255 CIFC12 H11 N O3P 21 21 216.917; 8.4769; 18.1729
90; 90; 90
1065.56Xue, Yu; Song, Peiran; Song, Zilan; Wang, Aoli; Tong, Linjiang; Geng, Meiyu; Ding, Jian; Liu, Qingsong; Sun, Liping; Xie, Hua; Zhang, Ao
Discovery of 4,7-Diamino-5-(4-phenoxyphenyl)-6-methylene-pyrimido[5,4- b]pyrrolizines as Novel Bruton's Tyrosine Kinase Inhibitors.
Journal of medicinal chemistry, 2018, 61, 4608-4627
1553265 CIFC12 H11.556 N0.889 O0.889P 1 21/c 112.27; 21.5852; 8.2015
90; 99.774; 90
2140.64Wu, Qiong; Zheng, Kangdi; Huang, Xiaoting; Li, Li; Mei, Wenjie
Tanshinone-IIA-Based Analogues of Imidazole Alkaloid Act as Potent Inhibitors To Block Breast Cancer Invasion and Metastasis in Vivo.
Journal of medicinal chemistry, 2018, 61, 10488-10501
1507499 CIFC12 H13 Br Cl N3 SP 1 21/c 121.335; 9.315; 14.491
90; 102.995; 90
2806.12Schröder, Jörg; Henke, Andreas; Wenzel, Herbert; Brandstetter, Hans; Stammler, Hans G.; Stammler, Anja; Pfeiffer, Wolf D.; Tschesche, Harald
Structure-Based Design and Synthesis of Potent Matrix Metalloproteinase Inhibitors Derived from a 6H-1,3,4-Thiadiazine Scaffold
Journal of Medicinal Chemistry, 2001, 44, 3231
1519611 CIFC12 H15 F N6 O4P 437.3545; 7.3545; 27.835
90; 90; 90
1505.6Yang, Qinghua; Kang, Jinfeng; Zheng, Liyun; Wang, Xue-Jun; Wan, Na; Wu, Jie; Qiao, Yan; Niu, Pengfei; Wang, Sheng-Qi; Peng, Youmei; Wang, Qingduan; Yu, Wenquan; Chang, Junbiao
Synthesis and biological evaluation of 4-substituted fluoronucleoside analogs for the treatment of hepatitis B virus infection.
Journal of medicinal chemistry, 2015, 58, 3693-3703
1503455 CIFC12 H16 Br N3 O2 SP 1 21/c 110.18411; 14.96067; 9.13052
90; 99.2862; 90
1372.9Baud, Matthias G. J.; Leiser, Thomas; Haus, Patricia; Samlal, Sharon; Wong, Ai Ching; Wood, Robert J.; Petrucci, Vanessa; Gunaratnam, Mekala; Hughes, Siobhan M.; Buluwela, Lakjaya; Turlais, Fabrice; Neidle, Stephen; Meyer-Almes, Franz-Josef; White, Andrew J. P.; Fuchter, Matthew J.
Defining the Mechanism of Action and Enzymatic Selectivity of Psammaplin A against Its Epigenetic Targets.
Journal of medicinal chemistry, 2012, 55, 1731-1750
1566550 CIFC12 H16 N2 O2P -17.7366; 7.9072; 10.7395
99.872; 102.594; 113.64
562.21Wittmann, Christopher; Bacher, Felix; Enyedy, Eva A.; Dömötör, Orsolya; Spengler, Gabriella; Madejski, Christian; Reynisson, Jóhannes; Arion, Vladimir B.
Highly Antiproliferative Latonduine and Indolo[2,3-<i>c</i>]quinoline Derivatives: Complex Formation with Copper(II) Markedly Changes the Kinase Inhibitory Profile.
Journal of medicinal chemistry, 2022, 65, 2238-2261
1553271 CIFC12 H17 N5 O SP 1 21/c 111.544; 13.204; 10.086
90; 112.081; 90
1424.6Ohui, Kateryna; Afanasenko, Eleonora; Bacher, Felix; Ting, Rachel Lim Xue; Zafar, Ayesha; Blanco-Cabra, Núria; Torrents, Eduard; Dömötör, Orsolya; May, Nóra V; Darvasiova, Denisa; Enyedy, Éva A; Popović-Bijelić, Ana; Reynisson, Jóhannes; Rapta, Peter; Babak, Maria V.; Pastorin, Giorgia; Arion, Vladimir B.
New Water-Soluble Copper(II) Complexes with Morpholine-Thiosemicarbazone Hybrids: Insights into the Anticancer and Antibacterial Mode of Action.
Journal of medicinal chemistry, 2019, 62, 512-530
1559415 CIFC12 H18 O2 SiP 1 21/c 114.814; 7.972; 10.798
90; 100.7; 90
1253Kleemiss, Florian; Justies, Aileen; Duvinage, Daniel; Watermann, Patrick; Ehrke, Eric; Sugimoto, Kunihisa; Fugel, Malte; Malaspina, Lorraine A.; Dittmer, Anneke; Kleemiss, Torsten; Puylaert, Pim; King, Nelly R.; Staubitz, Anne; Tzschentke, Thomas M.; Dringen, Ralf; Grabowsky, Simon; Beckmann, Jens
Sila-Ibuprofen.
Journal of medicinal chemistry, 2020
1553267 CIFC12 H22 Cl Cu N5 O4 SP -19.2626; 9.5087; 11.0617
89.565; 76.519; 67.742
873.29Ohui, Kateryna; Afanasenko, Eleonora; Bacher, Felix; Ting, Rachel Lim Xue; Zafar, Ayesha; Blanco-Cabra, Núria; Torrents, Eduard; Dömötör, Orsolya; May, Nóra V; Darvasiova, Denisa; Enyedy, Éva A; Popović-Bijelić, Ana; Reynisson, Jóhannes; Rapta, Peter; Babak, Maria V.; Pastorin, Giorgia; Arion, Vladimir B.
New Water-Soluble Copper(II) Complexes with Morpholine-Thiosemicarbazone Hybrids: Insights into the Anticancer and Antibacterial Mode of Action.
Journal of medicinal chemistry, 2019, 62, 512-530
1508820 CIFC12 H22 Cl2 N2 O8 PtP -18.2185; 10.0375; 12.4165
67.002; 71.136; 84.577
891.63Varbanov, Hristo P.; Jakupec, Michael A.; Roller, Alexander; Jensen, Frank; Galanski, Markus; Keppler, Bernhard K.
Theoretical Investigations and Density Functional Theory Based Quantitative Structure-Activity Relationships Model for Novel Cytotoxic Platinum(IV) Complexes.
Journal of medicinal chemistry, 2013, 56, 330-344
1505036 CIFC12 H26 Cl2 N2 O9 PtP n a 2123.5231; 10.6395; 8.1822
90; 90; 90
2047.79Reithofer, Michael R.; Valiahdi, Seied M.; Jakupec, Michael A.; Arion, Vladimir B.; Egger, Alexander; Galanski, Markus; Keppler, Bernhard K.
Novel di- and tetracarboxylatoplatinum(IV) complexes. Synthesis, characterization, cytotoxic activity, and DNA platination.
Journal of medicinal chemistry, 2007, 50, 6692-6699
1561876 CIFC13 H11 Cl Cu N4 S2P -18.6462; 9.7989; 10.1011
68.887; 71.065; 82.137
755Gou, Yi; Chen, MeiRong; Li, Shanhe; Deng, JunGang; Li, Jinlong; Fang, GuiHua; Yang, Feng; Huang, GuoJin
Dithiocarbazate-Copper Complexes for Bioimaging and Treatment of Pancreatic Cancer.
Journal of medicinal chemistry, 2021
1507655 CIFC13 H15 Fe N O SeC 1 2/c 117.983; 7.4102; 19.235
90; 93.649; 90
2558Gutiérrez-Hernández, Alejandro I; López-Cortés, José G; Ortega-Alfaro, M Carmen; Ramírez-Apan, M Teresa; Cázares-Marinero, José de Jesús; Toscano, Rubén A
Ferrocenylselenoamides: synthesis, characterization and cytotoxic properties.
Journal of medicinal chemistry, 2012, 55, 4652-4663
1557184 CIFC13 H15 N3 O5P 21 21 218.4194; 8.5433; 19.1641
90; 90; 90
1378.46Yang, Yaxi; Zhang, Rukang; Li, Zhaojun; Mei, Lianghe; Wan, Shili; Ding, Hong; Chen, Zhifeng; Xing, Jing; Feng, Huijin; Han, Jie; Jiang, Hualiang; Zheng, Mingyue; Luo, Cheng; Zhou, Bing
Discovery of Highly Potent, Selective, and Orally Efficacious p300/CBP Histone Acetyltransferases Inhibitors.
Journal of medicinal chemistry, 2020
1552488 CIFC13 H15 N3 O5 SP 1 21/c 112.3726; 11.22; 10.9487
90; 99.0665; 90
1500.92Shao, Xuwei; AbdelKhalek, Ahmed; Abutaleb, Nader S.; Velagapudi, Uday Kiran; Yoganathan, Sabesan; Seleem, Mohamed N.; Talele, Tanaji T.
Chemical Space Exploration around Thieno[3,2-<i>d</i>]pyrimidin-4(3<i>H</i>)-one Scaffold Led to a Novel Class of Highly Active <i>Clostridium difficile</i> Inhibitors.
Journal of medicinal chemistry, 2019
1553269 CIFC13 H18 Cl Cu N5 O SC 1 2/c 115.7566; 14.2967; 14.2703
90; 92.971; 90
3210.3Ohui, Kateryna; Afanasenko, Eleonora; Bacher, Felix; Ting, Rachel Lim Xue; Zafar, Ayesha; Blanco-Cabra, Núria; Torrents, Eduard; Dömötör, Orsolya; May, Nóra V; Darvasiova, Denisa; Enyedy, Éva A; Popović-Bijelić, Ana; Reynisson, Jóhannes; Rapta, Peter; Babak, Maria V.; Pastorin, Giorgia; Arion, Vladimir B.
New Water-Soluble Copper(II) Complexes with Morpholine-Thiosemicarbazone Hybrids: Insights into the Anticancer and Antibacterial Mode of Action.
Journal of medicinal chemistry, 2019, 62, 512-530
1559416 CIFC13 H18 O2P 1 21/c 114.465; 7.815; 10.435
90; 99.66; 90
1162.9Kleemiss, Florian; Justies, Aileen; Duvinage, Daniel; Watermann, Patrick; Ehrke, Eric; Sugimoto, Kunihisa; Fugel, Malte; Malaspina, Lorraine A.; Dittmer, Anneke; Kleemiss, Torsten; Puylaert, Pim; King, Nelly R.; Staubitz, Anne; Tzschentke, Thomas M.; Dringen, Ralf; Grabowsky, Simon; Beckmann, Jens
Sila-Ibuprofen.
Journal of medicinal chemistry, 2020
1552490 CIFC13 H18 O4P 1 21 15.7618; 19.4824; 11.8204
90; 90.0232; 90
1326.88Policarpo, Rocco L.; Decultot, Ludovic; May, Elizabeth; Kuzmič, Petr; Carlson, Samuel; Huang, Danny; Chu, Vincent; Wright, Brandon A.; Dhakshinamoorthy, Saravanakumar; Kannt, Aimo; Rani, Shilpa; Dittakavi, Sreekanth; Panarese, Joseph D.; Gaudet, Rachelle; Shair, Matthew D.
High-Affinity Alkynyl Bisubstrate Inhibitors of Nicotinamide <i>N</i>-Methyltransferase (NNMT).
Journal of medicinal chemistry, 2019
1553275 CIFC13 H19 N5 O SP 1 21/c 122.7776; 6.8585; 9.88
90; 98.889; 90
1524.92Ohui, Kateryna; Afanasenko, Eleonora; Bacher, Felix; Ting, Rachel Lim Xue; Zafar, Ayesha; Blanco-Cabra, Núria; Torrents, Eduard; Dömötör, Orsolya; May, Nóra V; Darvasiova, Denisa; Enyedy, Éva A; Popović-Bijelić, Ana; Reynisson, Jóhannes; Rapta, Peter; Babak, Maria V.; Pastorin, Giorgia; Arion, Vladimir B.
New Water-Soluble Copper(II) Complexes with Morpholine-Thiosemicarbazone Hybrids: Insights into the Anticancer and Antibacterial Mode of Action.
Journal of medicinal chemistry, 2019, 62, 512-530
1518236 CIFC13 H27 N O4 SP 1 21 16.0994; 22.475; 11.962
90; 91.895; 90
1638.9Maolanon, Alex R.; Villadsen, Jesper S.; Christensen, Niels J.; Hoeck, Casper; Friis, Tina; Harris, Pernille; Gotfredsen, Charlotte H.; Fristrup, Peter; Olsen, Christian A.
Methyl effect in azumamides provides insight into histone deacetylase inhibition by macrocycles.
Journal of medicinal chemistry, 2014, 57, 9644-9657
1505041 CIFC130 H133 Br4 Cl8 N16 O3.5 Os4P -113.8319; 14.1376; 18.3912
98.511; 107.338; 102.012
3271.8Schmid, Wolfgang F.; John, Roland O.; Mühlgassner, Gerhard; Heffeter, Petra; Jakupec, Michael A.; Galanski, Markus; Berger, Walter; Arion, Vladimir B.; Keppler, Bernhard K.
Metal-based paullones as putative CDK inhibitors for antitumor chemotherapy.
Journal of medicinal chemistry, 2007, 50, 6343-6355
1516882 CIFC14 H13 I O2P b c a7.8201; 15.7081; 21.1791
90; 90; 90
2601.6Yang, Yanping; Cui, Mengchao; Zhang, Xiaoyang; Dai, Jiapei; Zhang, Zhiyong; Lin, Chunping; Guo, Yuzhi; Liu, Boli
Radioiodinated Benzyloxybenzene Derivatives: A Class of Flexible Ligands Target to β-Amyloid Plaques in Alzheimer's Brains.
Journal of medicinal chemistry, 2014, 57, 6030-6042
1516883 CIFC14 H13 I O2P n a 216.1079; 7.2239; 28.327
90; 90; 90
1249.9Yang, Yanping; Cui, Mengchao; Zhang, Xiaoyang; Dai, Jiapei; Zhang, Zhiyong; Lin, Chunping; Guo, Yuzhi; Liu, Boli
Radioiodinated Benzyloxybenzene Derivatives: A Class of Flexible Ligands Target to β-Amyloid Plaques in Alzheimer's Brains.
Journal of medicinal chemistry, 2014, 57, 6030-6042
1503662 CIFC14 H13 N O3 S2P c a 2113.516; 9.108; 22.558
90; 90; 90
2777Agrawal, Arpita; de Oliveira, César Augusto F; Cheng, Yuhui; Jacobsen, Jennifer A.; McCammon, J. Andrew; Cohen, Seth M.
Thioamide hydroxypyrothiones supersede amide hydroxypyrothiones in potency against anthrax lethal factor.
Journal of medicinal chemistry, 2009, 52, 1063-1074
1505016 CIFC14 H14 Cl4 Cu2 N10P 1 21/a 18.346; 14.28; 8.376
90; 93.43; 90
996.5Tardito, Saverio; Bussolati, Ovidio; Maffini, Monica; Tegoni, Matteo; Giannetto, Marco; Dall'asta, Valeria; Franchi-Gazzola, Renata; Lanfranchi, Maurizio; Pellinghelli, Maria Angela; Mucchino, Claudio; Mori, Giovanni; Marchio, Luciano
Thioamido coordination in a thioxo-1,2,4-triazole copper(II) complex enhances nonapoptotic programmed cell death associated with copper accumulation and oxidative stress in human cancer cells.
Journal of medicinal chemistry, 2007, 50, 1916-1924
1506349 CIFC14 H16 Cu Fe N10 O5 SP 1 21/n 113.157; 13.641; 14.205
90; 115.98; 90
2291.8Belicchi-Ferrari, Marisa; Bisceglie, Franco; Casoli, Claudio; Durot, Stéphanie; Morgenstern-Badarau, Irène; Pelosi, Giorgio; Pilotti, Elisabetta; Pinelli, Silvana; Tarasconi, Pieralberto
Copper(II) and cobalt(III) pyridoxal thiosemicarbazone complexes with nitroprusside as counterion: syntheses, electronic properties, and antileukemic activity.
Journal of medicinal chemistry, 2005, 48, 1671-1675
1505019 CIFC14 H19.5 Cl2 N Na O6.75P 1 21 19.554; 39.491; 9.8412
90; 90.729; 90
3712.75Llinàs, Antonio; Burley, Jonathan C.; Box, Karl J.; Glen, Robert C.; Goodman, Jonathan M.
Diclofenac solubility: independent determination of the intrinsic solubility of three crystal forms.
Journal of medicinal chemistry, 2007, 50, 979-983
1553274 CIFC14 H21 N5 O SP 1 21/c 16.1236; 7.95; 30.956
90; 92.419; 90
1505.68Ohui, Kateryna; Afanasenko, Eleonora; Bacher, Felix; Ting, Rachel Lim Xue; Zafar, Ayesha; Blanco-Cabra, Núria; Torrents, Eduard; Dömötör, Orsolya; May, Nóra V; Darvasiova, Denisa; Enyedy, Éva A; Popović-Bijelić, Ana; Reynisson, Jóhannes; Rapta, Peter; Babak, Maria V.; Pastorin, Giorgia; Arion, Vladimir B.
New Water-Soluble Copper(II) Complexes with Morpholine-Thiosemicarbazone Hybrids: Insights into the Anticancer and Antibacterial Mode of Action.
Journal of medicinal chemistry, 2019, 62, 512-530
1552491 CIFC14 H22 O5P 21 21 215.7488; 9.3963; 27.2172
90; 90; 90
1470.2Policarpo, Rocco L.; Decultot, Ludovic; May, Elizabeth; Kuzmič, Petr; Carlson, Samuel; Huang, Danny; Chu, Vincent; Wright, Brandon A.; Dhakshinamoorthy, Saravanakumar; Kannt, Aimo; Rani, Shilpa; Dittakavi, Sreekanth; Panarese, Joseph D.; Gaudet, Rachelle; Shair, Matthew D.
High-Affinity Alkynyl Bisubstrate Inhibitors of Nicotinamide <i>N</i>-Methyltransferase (NNMT).
Journal of medicinal chemistry, 2019
1508918 CIFC14 H24 Cu N6 S2P -17.58; 12.83; 18.298
98.489; 99.605; 91.102
1733.6Palanimuthu, Duraippandi; Shinde, Sridevi Vijay; Somasundaram, Kumaravel; Samuelson, Ashoka G.
In Vitro and in Vivo Anticancer Activity of Copper Bis(thiosemicarbazone) Complexes.
Journal of medicinal chemistry, 2013, 56, 722-734
1503665 CIFC14 H24 N2 O2P 21 21 2110.2116; 10.8607; 13.1256
90; 90; 90
1455.7Fox, David J.; Reckless, Jill; Lingard, Hannah; Warren, Stuart; Grainger, David J.
Highly potent, orally available anti-inflammatory broad-spectrum chemokine inhibitors.
Journal of medicinal chemistry, 2009, 52, 3591-3595
1557186 CIFC15 H14 N4 O2P 21 21 215.8178; 16.9835; 28.2863
90; 90; 90
2794.9Yang, Yaxi; Zhang, Rukang; Li, Zhaojun; Mei, Lianghe; Wan, Shili; Ding, Hong; Chen, Zhifeng; Xing, Jing; Feng, Huijin; Han, Jie; Jiang, Hualiang; Zheng, Mingyue; Luo, Cheng; Zhou, Bing
Discovery of Highly Potent, Selective, and Orally Efficacious p300/CBP Histone Acetyltransferases Inhibitors.
Journal of medicinal chemistry, 2020
1566736 CIFC15 H14 O3P 21 21 215.5437; 8.4551; 52.42
90; 90; 90
2457.06Müller, Christoph; Gleixner, Jakob; Tahk, Maris-Johanna; Kopanchuk, Sergei; Laasfeld, Tõnis; Weinhart, Michael; Schollmeyer, Dieter; Betschart, Martin U.; Lüdeke, Steffen; Koch, Pierre; Rinken, Ago; Keller, Max
Structure-Based Design of High-Affinity Fluorescent Probes for the Neuropeptide Y Y<sub>1</sub> Receptor.
Journal of medicinal chemistry, 2022, 65, 4832-4853
1529429 CIFC15 H17 F3 O3P 21 21 218.511; 11.945; 14.173
90; 90; 90
1440.9Yang, Zhong-Jin; Ge, Wei-Zhi; Li, Qiu-Ying; Lu, Yaxin; Gong, Jian-Miao; Kuang, Bei-Jia; Xi, Xiaonan; Wu, Haiting; Zhang, Quan; Chen, Yue
Syntheses and Biological Evaluation of Costunolide, Parthenolide, and Their Fluorinated Analogues.
Journal of medicinal chemistry, 2015, 58, 7007-7020
1517410 CIFC15 H20 O3P 21 21 216.1945; 10.289; 21.907
90; 90; 90
1396.2Long, Jing; Zhang, Shan-Feng; Wang, Pan-Pan; Zhang, Xue-Mei; Yang, Zhong-Jin; Zhang, Quan; Chen, Yue
Total syntheses of parthenolide and its analogues with macrocyclic stereocontrol.
Journal of medicinal chemistry, 2014, 57, 7098-7112
1565895 CIFC15 H20 O4P 21 21 218.2975; 12.0102; 13.9497
90; 90; 90
1390.15Liu, Xingchen; Wang, Cheng; Li, Shang; Qu, Lailiang; Yin, Fucheng; Lu, Dehua; Luo, Heng; Chen, Xinye; Luo, Zhongwen; Cui, Ningjie; Wang, Xiaobing; Kong, Lingyi
Parthenolide Derivatives as PKM2 Activators Showing Potential in Colorectal Cancer.
Journal of medicinal chemistry, 2021, 64, 17304-17325
1553268 CIFC15 H23 Cl Cu N6 O2 SP 1 21/c 19.3959; 19.8889; 10.9744
90; 108.366; 90
1946.37Ohui, Kateryna; Afanasenko, Eleonora; Bacher, Felix; Ting, Rachel Lim Xue; Zafar, Ayesha; Blanco-Cabra, Núria; Torrents, Eduard; Dömötör, Orsolya; May, Nóra V; Darvasiova, Denisa; Enyedy, Éva A; Popović-Bijelić, Ana; Reynisson, Jóhannes; Rapta, Peter; Babak, Maria V.; Pastorin, Giorgia; Arion, Vladimir B.
New Water-Soluble Copper(II) Complexes with Morpholine-Thiosemicarbazone Hybrids: Insights into the Anticancer and Antibacterial Mode of Action.
Journal of medicinal chemistry, 2019, 62, 512-530
1517409 CIFC15 H23 N O3P 21 21 2111.012; 11.015; 12.183
90; 90; 90
1477.8Long, Jing; Zhang, Shan-Feng; Wang, Pan-Pan; Zhang, Xue-Mei; Yang, Zhong-Jin; Zhang, Quan; Chen, Yue
Total syntheses of parthenolide and its analogues with macrocyclic stereocontrol.
Journal of medicinal chemistry, 2014, 57, 7098-7112

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