Asymmetric Synthesis of 3,4-Disubstituted 2-(Trifluoromethyl)pyrrolidines through Rearrangement of Chiral 2-(2,2,2-Trifluoro-1-hydroxyethyl)azetidines.
Authors of publication
Dolfen, Jeroen; Boydas, Esma Birsen; Van Speybroeck, Veronique; Catak, Saron; Van Hecke, Kristof; D'hooghe, Matthias
Journal of publication
The Journal of organic chemistry
Year of publication
2017
Journal volume
82
Journal issue
19
Pages of publication
10092 - 10109
a
27.2782 ± 0.0005 Å
b
27.2782 ± 0.0005 Å
c
10.61163 ± 0.00018 Å
α
90°
β
90°
γ
120°
Cell volume
6838.2 ± 0.2 Å3
Cell temperature
100 ± 0.1 K
Ambient diffraction temperature
100 ± 0.1 K
Number of distinct elements
5
Space group number
146
Hermann-Mauguin space group symbol
R 3
Hall space group symbol
R 3
Residual factor for all reflections
0.0911
Residual factor for significantly intense reflections
0.0826
Weighted residual factors for significantly intense reflections
0.2245
Weighted residual factors for all reflections included in the refinement
0.2364
Goodness-of-fit parameter for all reflections included in the refinement
