Synthetic ansamycins prepared by a ring-expanding Claisen rearrangement. Synthesis and biological evaluation of ring and conformational analogues of the Hsp90 molecular chaperone inhibitor geldanamycin.
Authors of publication
McErlean, Christopher S. P.; Proisy, Nicolas; Davis, Christopher J.; Boland, Nicola A.; Sharp, Swee Y.; Boxall, Kathy; Slawin, Alexandra M. Z.; Workman, Paul; Moody, Christopher J.
Journal of publication
Organic & biomolecular chemistry
Year of publication
2007
Journal volume
5
Journal issue
3
Pages of publication
531 - 546
a
8.8832 ± 0.0012 Å
b
10.3813 ± 0.0015 Å
c
12.0879 ± 0.0017 Å
α
81.631 ± 0.002°
β
81.67 ± 0.002°
γ
78.225 ± 0.002°
Cell volume
1072 ± 0.3 Å3
Cell temperature
125 ± 2 K
Ambient diffraction temperature
125 ± 2 K
Number of distinct elements
4
Space group number
2
Hermann-Mauguin space group symbol
P -1
Hall space group symbol
-P 1
Residual factor for all reflections
0.0834
Residual factor for significantly intense reflections
0.0681
Weighted residual factors for significantly intense reflections
0.1683
Weighted residual factors for all reflections included in the refinement
0.1813
Goodness-of-fit parameter for all reflections included in the refinement
