Identification of ARUK2002821 as an isoform-selective PI5P4Kα inhibitor
Authors of publication
Willems, Henriëtte M. G.; Edwards, Simon; Boffey, Helen K.; Chawner, Stephen J.; Green, Christopher; Romero, Tamara; Winpenny, David; Skidmore, John; Clarke, Jonathan H.; Andrews, Stephen P.
Journal of publication
RSC Medicinal Chemistry
Year of publication
2023
a
11.3629 ± 0.0003 Å
b
7.1919 ± 0.0002 Å
c
22.2901 ± 0.0006 Å
α
90°
β
101.206 ± 0.0012°
γ
90°
Cell volume
1786.84 ± 0.08 Å3
Cell temperature
180 ± 2 K
Ambient diffraction temperature
180 ± 2 K
Number of distinct elements
5
Space group number
14
Hermann-Mauguin space group symbol
P 1 21/c 1
Hall space group symbol
-P 2ybc
Residual factor for all reflections
0.036
Residual factor for significantly intense reflections
0.0306
Weighted residual factors for significantly intense reflections
0.0746
Weighted residual factors for all reflections included in the refinement
0.0772
Goodness-of-fit parameter for all reflections included in the refinement
