Synthesis and structure-activity evaluation of isatin-β-thiosemicarbazones with improved selective activity toward multidrug-resistant cells expressing P-glycoprotein.
Authors of publication
Hall, Matthew D.; Brimacombe, Kyle R.; Varonka, Matthew S.; Pluchino, Kristen M.; Monda, Julie K.; Li, Jiayang; Walsh, Martin J.; Boxer, Matthew B.; Warren, Timothy H.; Fales, Henry M.; Gottesman, Michael M.
Journal of publication
Journal of medicinal chemistry
Year of publication
2011
Journal volume
54
Journal issue
16
Pages of publication
5878 - 5889
a
16.7856 ± 0.0009 Å
b
5.4114 ± 0.0003 Å
c
16.1237 ± 0.0008 Å
α
90°
β
100.73 ± 0.001°
γ
90°
Cell volume
1438.97 ± 0.13 Å3
Cell temperature
100 ± 2 K
Ambient diffraction temperature
100 ± 2 K
Number of distinct elements
5
Space group number
14
Hermann-Mauguin space group symbol
P 1 21/c 1
Hall space group symbol
-P 2ybc
Residual factor for all reflections
0.0403
Residual factor for significantly intense reflections
0.0332
Weighted residual factors for significantly intense reflections
0.0818
Weighted residual factors for all reflections included in the refinement
0.0854
Goodness-of-fit parameter for all reflections included in the refinement
