Enantioselective synthesis of a highly potent selective serotonin reuptake inhibitor. An application of imidazolidinone catalysis to the alkylation of indoles with an alpha,beta-disubstituted alpha,beta-unsaturated aldehyde.
Authors of publication
King, H. Dalton; Meng, Zhaoxing; Denhart, Derek; Mattson, Ronald; Kimura, Roy; Wu, Dedong; Gao, Qi; Macor, John E.
Journal of publication
Organic letters
Year of publication
2005
Journal volume
7
Journal issue
16
Pages of publication
3437 - 3440
a
9.0617 ± 0.0001 Å
b
9.9837 ± 0.0001 Å
c
18.1625 ± 0.0002 Å
α
90°
β
90°
γ
90°
Cell volume
1643.15 ± 0.03 Å3
Cell temperature
293 ± 2 K
Ambient diffraction temperature
293 ± 2 K
Number of distinct elements
4
Space group number
19
Hermann-Mauguin space group symbol
P 21 21 21
Hall space group symbol
P 2ac 2ab
Residual factor for all reflections
0.0275
Residual factor for significantly intense reflections
0.0272
Weighted residual factors for significantly intense reflections
0.0743
Weighted residual factors for all reflections included in the refinement
0.0746
Goodness-of-fit parameter for all reflections included in the refinement