Synthesis of 4-alkyl-, 4-aryl- and 4-arylamino-5-aminoisoquinolin-1-ones and identification of a new PARP-2 selective inhibitor.
Authors of publication
Sunderland, Peter T.; Dhami, Archana; Mahon, Mary F.; Jones, Louise A.; Tully, Sophie R.; Lloyd, Matthew D.; Thompson, Andrew S.; Javaid, Hashim; Martin, Niall M. B.; Threadgill, Michael D.
Journal of publication
Organic & biomolecular chemistry
Year of publication
2011
Journal volume
9
Journal issue
3
Pages of publication
881 - 891
a
8.618 ± 0.0004 Å
b
9.912 ± 0.0004 Å
c
10.226 ± 0.0005 Å
α
114.347 ± 0.002°
β
108.553 ± 0.002°
γ
100.738 ± 0.002°
Cell volume
701.65 ± 0.06 Å3
Cell temperature
150 ± 2 K
Ambient diffraction temperature
150 ± 2 K
Number of distinct elements
5
Space group number
2
Hermann-Mauguin space group symbol
P -1
Hall space group symbol
-P 1
Residual factor for all reflections
0.0421
Residual factor for significantly intense reflections
0.0303
Weighted residual factors for significantly intense reflections
0.0642
Weighted residual factors for all reflections included in the refinement
0.068
Goodness-of-fit parameter for all reflections included in the refinement