Fused imidazoles as potential chemical scaffolds for inhibition of heat shock protein 70 and induction of apoptosis. Synthesis and biological evaluation of phenanthro[9,10-d]imidazoles and imidazo[4,5-f][1,10]phenanthrolines.
Authors of publication
Patel, Alpa; Sharp, Swee Y.; Hall, Katelan; Lewis, William; Stevens, Malcolm F. G.; Workman, Paul; Moody, Christopher J.
Journal of publication
Organic & biomolecular chemistry
Year of publication
2016
Journal volume
14
Journal issue
16
Pages of publication
3889 - 3905
a
10.928 ± 0.0018 Å
b
11.778 ± 0.0019 Å
c
13.075 ± 0.002 Å
α
87.909 ± 0.003°
β
87.569 ± 0.003°
γ
77.316 ± 0.002°
Cell volume
1639.7 ± 0.5 Å3
Cell temperature
90 ± 2 K
Ambient diffraction temperature
90 ± 2 K
Number of distinct elements
5
Space group number
2
Hermann-Mauguin space group symbol
P -1
Hall space group symbol
-P 1
Residual factor for all reflections
0.0755
Residual factor for significantly intense reflections
0.061
Weighted residual factors for significantly intense reflections
0.1636
Weighted residual factors for all reflections included in the refinement
0.1798
Goodness-of-fit parameter for all reflections included in the refinement
