Fused imidazoles as potential chemical scaffolds for inhibition of heat shock protein 70 and induction of apoptosis. Synthesis and biological evaluation of phenanthro[9,10-d]imidazoles and imidazo[4,5-f][1,10]phenanthrolines.
Authors of publication
Patel, Alpa; Sharp, Swee Y.; Hall, Katelan; Lewis, William; Stevens, Malcolm F. G.; Workman, Paul; Moody, Christopher J.
Journal of publication
Organic & biomolecular chemistry
Year of publication
2016
Journal volume
14
Journal issue
16
Pages of publication
3889 - 3905
a
7.3173 ± 0.0002 Å
b
15.5645 ± 0.0004 Å
c
13.0802 ± 0.0003 Å
α
90°
β
90°
γ
90°
Cell volume
1489.71 ± 0.07 Å3
Cell temperature
90 ± 2 K
Ambient diffraction temperature
90 ± 2 K
Number of distinct elements
3
Space group number
33
Hermann-Mauguin space group symbol
P n a 21
Hall space group symbol
P 2c -2n
Residual factor for all reflections
0.03
Residual factor for significantly intense reflections
0.0294
Weighted residual factors for significantly intense reflections
0.0788
Weighted residual factors for all reflections included in the refinement
0.0795
Goodness-of-fit parameter for all reflections included in the refinement
