Fused imidazoles as potential chemical scaffolds for inhibition of heat shock protein 70 and induction of apoptosis. Synthesis and biological evaluation of phenanthro[9,10-d]imidazoles and imidazo[4,5-f][1,10]phenanthrolines.
Authors of publication
Patel, Alpa; Sharp, Swee Y.; Hall, Katelan; Lewis, William; Stevens, Malcolm F. G.; Workman, Paul; Moody, Christopher J.
Journal of publication
Organic & biomolecular chemistry
Year of publication
2016
Journal volume
14
Journal issue
16
Pages of publication
3889 - 3905
a
12.5059 ± 0.001 Å
b
32.64 ± 0.002 Å
c
9.2776 ± 0.0006 Å
α
90°
β
93.765 ± 0.007°
γ
90°
Cell volume
3778.9 ± 0.5 Å3
Cell temperature
120 ± 2 K
Ambient diffraction temperature
120 ± 2 K
Number of distinct elements
4
Space group number
14
Hermann-Mauguin space group symbol
P 1 21/c 1
Hall space group symbol
-P 2ybc
Residual factor for all reflections
0.1334
Residual factor for significantly intense reflections
0.0919
Weighted residual factors for significantly intense reflections
0.1916
Weighted residual factors for all reflections included in the refinement
0.2091
Goodness-of-fit parameter for all reflections included in the refinement
